Marwa nasr biography examples
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Mecca
Holiest city in Islam, city in Saudi Arabia
For other uses, see Mecca (disambiguation).
City in Mecca Province, Saudi Arabia
Mecca (; officially Makkah al-Mukarramah,[a] commonly shortened to Makkah[b]) is the capital of Mecca Province in the Hejaz region of western Saudi Arabia; it is the holiest city according to Islam.[4] It is 70 km (43 mi) inland from Jeddah on the Red Sea, in a narrow valley 277 m (909 ft) above sea level. Its metropolitan population in 2022 was 2.4 million, making it the third-most populated city in Saudi Arabia after Riyadh and Jeddah. Around 44.5% of the population are Saudi citizens and around 55.5% are Muslim foreigners from other countries.[5] Pilgrims more than triple the population number every year during the Ḥajjpilgrimage, observed in the twelfth Hijri month of Dhūl-Ḥijjah.[6] With over 10.8 million international visitors in 2023, Mecca was one of the te
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Abstract
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown synergistic effects on tumor progression. Seeking to develop dual BRAF/VEGFR-2 inhibitors, we synthesized 18 amino-benzothiazole derivatives with structural similarities to reported dual inhibitors. Four compounds—4a, 4f, 4l, and 4r—demonstrated remarkable cytotoxicity, with IC50 values ranging from 3.58 to 15.36 μM, against three cancer cell lines. Furthermore, these compounds showed IC50 values of 38.77–66.22 μM in the case of a normal fängelse line, which was significantly safer than the reference, sorafenib. Subsequent investigation revealed that compound 4f exhibited the capacity to hämma the BRAF and VEGFR-2 enzymes, with IC50 values similar to sorafenib (0.071 and 0.194 μM, respectively). Moreover, compound 4f • Supreme Leader of Iran since 1989 Not to be confused with his predecessor, Ruhollah Khomeini. Ali Khamenei Khamenei in 2025 Incumbent IncumbentAli Khamenei
Assumed office
6 August 1989[nb]President Preceded by Ruhollah Khomeini In office
9 October 1981 – 16 August 1989Supreme Leader Prime Minister Mir-Hossein Mousavi Preceded by Mohammad-Ali Rajai Succeeded by Akbar Hashemi Rafsanjani In office
7 February 1988 – 4 June 1989Appointed by Ruhollah Khomeini Preceded by Office established Succeeded by Akbar Hashemi Rafsanjani In office
15 August 1983 – 4 June 1989Constituency Tehran Province[1] Majority 2,800,353 (87.8%)[2] In office
28 May 1980 – 13 October 1981Constituency Tehran, Rey and Shemiranat Majority 1,405,976 (65.8%)[3] Assumed office
14 January 1980Appointed by Ruhollah Khomeini